A UK retrospective analysis of recurrent cardiovascular events following acute myocardial infarction in patients with multivessel disease and additional risk factors

Abstract Background Patients with multivessel disease (MVD) are at increased risk of recurrent cardiovascular (CV) events in the early period after acute myocardial infarction (AMI) compared to patients without MVD, possibly due atherosclerotic burden. Moreover, many have additional factors such as older age, peripheral artery (PAD), prior AMI or diabetes that could further increase events. Real-world evidence regarding impact CV on outcomes MVD remains sparse. Purpose To assess clinical a UK cohort and factors. Methods A retrospective analysis (January 1, 2008–December 31, 2018, inclusive) was conducted using Clinical Practice Research Datalink database linked Hospital Episode Statistics Office National databases identify confirmed diagnosis within study least one non-fatal (MI) code their first recorded diagnosis. The effect assessed by comparing diagnosed index those no concurrent (MVD+DM MVD-DM cohorts, respectively). were also but two including: age >65 years, PAD MI (MVD2RF+ cohort), single none aforementioned (MVD2RF- cohort). Major adverse (MACE) defined composite AMI, stroke death. Results Of 78,128 identified, 19,768 52,197 eligible for inclusion MVD+DM cohorts respectively. Occurrence MACE similar between both 90 days (15% vs. 14%) 1 year (19% 17%) post-AMI; however, all-cause mortality significantly higher over (p<0.001). In subset diabetes, 7,531 44,666 met criteria MVD2RF+ MVD2RF- substantially proportion experienced post-MI (90 days: 45% 9%; year: 56% 11%), accounting majority Kaplan-Meier survival revealed than Conclusions Having multiple including history increases particularly AMI. Strategies reduce systemic burden these needed. Funding Acknowledgement Type funding sources: Private company. Main source(s): CSL Behring